Simparico Trio, will not be given to my dog ever again. Product Overview. Not wanting to play, shivering, and drinking excessively. Two days later, she is doing better, but not 100% yet. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. She was terrified and we were too. We started the medication on Dec. 1st and 3 days later it started with vomiting and loss of appetite. The following day he died. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? I hope this comment will save you and your pets from unnecessary trouble. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. He has become more aggressive and has been growling at me sometimes when I try to move him. This can help with feelings of anxiety, stress, and fear." The only thing we changed after his checkup if Feb. was his flea and tick treatment. He is also running a fever so is not out of the woods. Is the added expense worth the trouble to insure your beloved pet? Now do you get the connection? Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Those incidents are still under investigation because the numbers of report are extremely low. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. I paid $120 for 6 months of poison. Ticks are horrible here in Maine. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. I have to turn him around and lead him away. Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. He had it once before with no issues. My vet is aware of this and prescribed simparica. Somedays he will have 2 and then he will go for a couple days without having any issues. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. but wasnt allowed in with him. Now we are waiting for the verdict: whether its an infection in his bladder or stones. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. Thank you! After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. You keep your dog cages? Started downhill health issues with initial dose. He was a dog you could pick up anytime and he was good as gold. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. He seems back to his normal self and playing with his toys, but we will not continue the following doses! I am very worried I called the vet they said oops sorry they made a mistake. She didn't make it to the next day and died overnight. I am so sad to read what is happening to some pets. And both of my other labs, basically house dogs, ended up with a droopy left eye. It went away. Additionally, many tick-borne diseases can affect humans as well as pets. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Use a collar or topical if you need to. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. A week after I lost her I got COVID and was in the hospital for 20 days. Those with Diarrhea symptom, did it look like mucus in their pets stool? It is better but not gone. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. All antiparasitics for dogs lower the seizure threshold. This is worth the cost to buy a six-pack of protection. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! Advised I could call Simparica for reimbursement or to report side effects. Tasty, liver-flavored chewable tablet is easy to administer. The Maltese mix is lethargic and wont jump on bed or couch. He had kidney failure he had seizures he had nervous system problems. she has shaking off and on . This is because it doesn't kill adult heartworms. CET Enzymatic Oral Hygiene Chews for Dogs. I only stumbled on the side effects of this drug via a post on a Spinone group. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. We got to the Animal Hospital . On 01/07/21, we gave our 11 year old black lab, Rawley, a 2nd dose of Simparico TRIO. We were so upset - I vowed to never use oral flea treatment again. My other two dogs had a little loose stool but nothing else. Please do not use this drug. Her blood work came back fine. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. I gave my 1 year old collie cross Simparica flea and tick medication. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. After reading all of supporting reviews, I will never give him this again. Random vomitting is no fun either. However, they are possible, so it is better to know they might happen. I am so angry. Anyway, he prescribed him pain relief for 7 days. 24 hours after, we noticed diarrhea. Update June 7th. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. Today the seizure like attack happened even though he is on the steroids. Its now about May 16th 2021. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. After reading all your entries, i'm thrilled i chose to take her off of it. Has anyone else experienced this? Hope all is well. Simparica may also cause the following side effects: Vomiting Diarrhea Lethargy Contact your veterinarian if your dog experiences any side effects as a result of taking Simparica. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. - she's had several episodes since then. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. Simparica Trio should be used with caution in dogs with a history of seizures. I to also gave my best friend Simparica as recommended by the vet. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. I hate that I did this to her and I hate that the Vet does not seem to care. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. But this month we are at day 7 and I expect the diarrhea it to continue. I should have kept with my gut feeling about any of these oral meds. He has horrible water like stools. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. The vet said not to give it. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. On Jan 4th for the first time. I gave the 1st one to my dog, 1st of this month. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. Best of luck. How long did these symptoms last? Thank you all so much!!!! Would appreciate any opinion you all may have. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. Now, here we are one month later and I just gave him the second dose about two hours ago. X-rays fine. 300+ Cute Cat Names for Every Kind of Kitty. My American Akita puppy took this pill on August 8th. Gave my Olde English Bulldog puppies Simparica Trio on 4/7/21 they are almost 4 month now. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. Decreased conscious proprioception. Simparica Trio Recall can be trusted with their product. Our pick for best oral flea control product for dogs is Simparica TRIO, a chewable tablet that is fast-acting and kills more parasites than any other oral product. I wish every one the best. She will never have this again, I can assure you! Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. Puppy is having seizures and has aspirated pneumonia. Simparica is pretty new in England and it seems they are trialling it. She was shaking like she was freezing. Wonder why PetSmart offers this if there are so many concerns reported. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Any advice on the diarrhea? She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. Im certain that its the simparica. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. Is it too late? But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! Dogs Naturally Market is a good source to check out. She also started drinking excessively, and peeing in the house. Will NEVER give this to my dog again. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. Lethargic and confused. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. She never did that before! Kristine, unfortunately my sweet Dolly passed away on October 9th. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. My family saw it , I did not . I wish I could get it out of her system. Not known if there be permanent after-effects. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. A month later, he was at doggie daycare and we picked him up and he was panting frantically. In total we spend around $780 trying to control/stop the tremors & seizures. Naturally, I want to make sure that she never has to go through that again. 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